Hands on with Monolix

The participants will have the chance to work on a hands-on exercise between the two sessions. A presentation of the solution of the hands-on exercise will be done at the beginning of the second day and the solution will also be explained step by step in the slides.

Monday 7th November, 2:30pm-5:30pm Malaysian Time
Development of population pharmacokinetic models with MONOLIX
  • Theoretical recap on the population approach
  • Data formatting and data visualization
  • Setup of a Monolix run (data definition, structural model, statistical model)
  • Estimation tasks and model diagnostic with the plots and statistical tests
  • Stepwise development of the structural model (using the model libraries)
  • Stepwise development of the statistical model, including covariate search
  • Presentation of the hands-on exercise

    • Tuesday 8th November, 2:30pm-5:30pm Malaysian Time
    Development of population PKPD models with Monolix and simulation of a new scenarios in Simulx
  • Presentation of the hands-on solution
  • Mlxtran language for custom model writing
  • PKPD model development strategies (sequential, joint)
  • Export of a Monolix run to Simulx
  • Definition of the simulation of new scenarios, in particular new dosing regimens
  • Post-processing of simulation results
  • Presentation of the hands-on exercise
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    The registration for presymposium workshop is CLOSED

    Instruction and solutions for hands-on exercise will also provided on the second day.